Dr Vilius Franckevičius

Dr Vilius Franckevičius

Lecturer

B7A Faraday Building
Lancaster University
Bailrigg
Lancaster
United Kingdom
LA1 4YB

+44 (0) 1524 593748

Research Summary

Vilius is a lecturer in organic chemistry at the Department of Chemistry. He was previously a Research and Teaching Fellow in the group of Professor Richard J K Taylor at the University of York, which followed a post-doctoral position in Munich with Professor Dirk Trauner and PhD studies with Professor Steven V Ley at the University of Cambridge. His research interests centre around synthetic organic chemistry and catalysis, and encompass the development of new transition-metal-catalysed reaction methodologies, studies of organometallic reaction mechanisms and catalytic asymmetric synthesis.

Further Research Information

Our research programme lies at the heart of organic synthesis and contemporary metal catalysis, and focuses on the discovery and development of new waste-minimised and sustainable synthetic tools for the efficient assembly of organic molecules in an asymmetric manner. We are, in particular, interested in decarboxylative C=C bond formation methods, which, unlike traditional catalytic cross-coupling approaches, avoid the use of basic or harsh reaction conditions and, save for carbon dioxide, which is easily removable, do not generate stoichiometric amounts of by-products or harmful waste.

Diagram of decarboxylative cross-coupling processes (Click to enlarge)

An example of this approach, recently developed by us, is the decarboxylative palladium-catalysed allylation of oxindoles, which utilises readily accessible oxindole allyl ester substrates and enables the installation of a quaternary all-carbon stereogenic centre in oxindole products with high enantioselectivity under extremely mild reaction conditions (Org. Lett. 2011, 13, 4264).

Publications

Recent Publications:

  • Palladium-Catalysed Decarboxylative Alkenylation of Stabilised Enolates. S. P. Schröder, P. Jackson, N. J. Taylor and V. Franckevičius, 2012, manuscript in preparation.
  • A Photochromic Agonist of NMDA Receptors. V. Franckevičius, L. Laprell, M. Sumser and D. Trauner, 2012, manuscript in preparation.
  • Copper-Catalysed Approach to Spirocyclic Oxindoles via a Direct C-H, Ar-H Functionalisation. C. L. Moody, V. Franckevičius, P. Drouhin, J. E. M. N. Klein and R. J. K. Taylor, Tetrahedron Lett. 2012, 53, 1897.
  • Asymmetric Decarboxylative Allylation of Oxindoles. V. Franckevičius, J. D. Cuthbertson, M. Pickworth, D. S. Pugh and R. J. K. Taylor, Org. Lett. 2011, 13, 4264. Featured in Synfacts 2011, 10, 1087.